r/science • u/chilladipa • 7h ago

Health Histologic Features and Clinical Outcomes of Lean Metabolic Dysfunction–Associated Steatotic Liver Disease

https://jamanetwork.com/journals/jama/fullarticle/2854668?guestAccessKey=7c9d24b8-2df6-4851-b219-227e1b741a23&utm_source=fbpage&utm_medium=social_jama&utm_term=22126372770&utm_campaign=article_alert&linkId=1014886352&fbclid=Iwb21leAUrJwpjbGNrBSsm22V4dG4DYWVtAjExAHBkb2YFc3J0YwZhcHBfaWQMMzUwNjg1NTMxNzI4AAEeD6HJmTNTDrCcsYoMOXtB-NnigqZUIYTIZB2wEE4ReAqLMttazj2_U8vCKXM_aem_IvXsAndGv7wSnGc29b3eOw
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u/chilladipa 7h ago

Key Points Question Do patients with lean metabolic dysfunction–associated steatotic liver disease (MASLD) experience different risks of adverse clinical outcomes than patients with overweight/obese MASLD, and how accurate are noninvasive tests in this population?

Findings In this multinational cohort of 18 326 patients with MASLD, 6.7% were lean by body mass index (6.0% by waist circumference). Lean patients had fewer metabolic comorbidities and less severe histologic disease than patients with overweight or obesity; however, there was no significant difference in all-cause mortality or clinical events and lean body status did not affect outcomes, whereas fibrosis stage did.

Meaning Patients with lean MASLD have similar risk of adverse clinical outcomes as patients with overweight/obese MASLD; risk stratification is more accurate with liver stiffness measurement than Fibrosis-4 score.